Characterization of a Novel Influenza Hemagglutinin, H15: Criteria for Determination of Influenza A Subtypes
Identifieur interne : 001C77 ( Main/Exploration ); précédent : 001C76; suivant : 001C78Characterization of a Novel Influenza Hemagglutinin, H15: Criteria for Determination of Influenza A Subtypes
Auteurs : Carolin Röhm ; Nannan Zhou ; Jochen Süss [Allemagne] ; John Mackenzie [Australie] ; Robert G. WebsterSource :
- Virology [ 0042-6822 ] ; 1996.
English descriptors
- Teeft :
- Academic press, Allantoic fluid, Amino, Amino acid homologies, Amino acid homology, Amino acid level, Amino acid positions, Amino acid sequence, Amino acid sequences, Amino acids, Antigenic, Antigenic sites, Antiserum, Aquatic birds, Assay, Australian viruses, Avian, Avian influenza viruses, Chicken antiserum, Cleavage site, Different subtypes, Double immunodiffusion assay, Double immunodiffusion assays, Embryonated chicken eggs, Equine, Genbank, Gene, Genetic characterization, Geographical separation, Globular, Globular head, Globular head region, Glycosylation, Hemagglutinin, Hemagglutinin genes, Homology, Horizontal distances, Immunodiffusion, Influenza, Influenza hemagglutinin, Influenza virus, Influenza virus hemagglutinin, Influenza viruses, Insertion, Intelligenetics suite, Jude research hospital, Kawaoka, Mature peptide, Molecular analysis, Molecular biology, Monospecific antisera, Nonhomologous recombination, Nonspecific inhibition, Nucleoprotein gene, Nucleotide, Nucleotide changes, Nucleotide sequences, Nucleotide sequences encoding, Nucleotide substitutions, Nucleotide tree, Oligonucleotide primers, Other subtypes, Peptide, Phylogenetic, Phylogenetic analysis, Phylogenetic relationship, Phylogenetic tree, Potential glycosylation sites, Primer sequences, Reassortant virus, Recombination, Recombination events, Reference antisera, Rohm, Same subtype, Selective pressure, Sequence analysis, Sequencing, Serological assays, Signal peptide, Spacing branches, Subtype, Subtypes, Subunit, Vertical lines, Vira, Virol, Virology, Virology rohm, Virus, Western equine encephalitis virus, Wild birds.
Abstract
Abstract: Two viruses with a novel hemagglutinin (HA), A/duck/Australia/341/83 and A/shearwater/West Australia/2576/79, have been isolated from a duck and a shorebird in Australia. Hemagglutination inhibition and double immunodiffusion assays failed to reveal cross-reactivity with any of the known subtypes (H1 to H14). We therefore propose that these viruses constitute a new HA subtype, H15. Sequence analysis of the HA genes confirmed the serologic findings. When compared at the amino acid level, the HA1 region of the H15 subtype differs from those of the other subtypes by 30% and more. This degree of heterogeneity is also found among HA genes of other subtypes. Thus we propose that amino acid sequence data should be evaluated when determining the HA subtypes of influenza A viruses. Sequence comparison and phylogenetic analysis suggested that the HA subtype H15 is most closely related to the H7. Compared to the H7 HA, the H15 acquired a 30-nucleotide insertion within HA1 at position 253 which is located in the globular head of the molecule. This finding suggests that RNA recombination, although a rare event in nature, may play an important role in the evolution of influenza viruses.
Url:
DOI: 10.1006/viro.1996.0145
Affiliations:
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Hemagglutination inhibition and double immunodiffusion assays failed to reveal cross-reactivity with any of the known subtypes (H1 to H14). We therefore propose that these viruses constitute a new HA subtype, H15. Sequence analysis of the HA genes confirmed the serologic findings. When compared at the amino acid level, the HA1 region of the H15 subtype differs from those of the other subtypes by 30% and more. This degree of heterogeneity is also found among HA genes of other subtypes. Thus we propose that amino acid sequence data should be evaluated when determining the HA subtypes of influenza A viruses. Sequence comparison and phylogenetic analysis suggested that the HA subtype H15 is most closely related to the H7. Compared to the H7 HA, the H15 acquired a 30-nucleotide insertion within HA1 at position 253 which is located in the globular head of the molecule. This finding suggests that RNA recombination, although a rare event in nature, may play an important role in the evolution of influenza viruses.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li></country><region><li>Berlin</li></region><settlement><li>Berlin</li></settlement></list><tree><noCountry><name sortKey="Rohm, Carolin" sort="Rohm, Carolin" uniqKey="Rohm C" first="Carolin" last="Röhm">Carolin Röhm</name><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name><name sortKey="Zhou, Nannan" sort="Zhou, Nannan" uniqKey="Zhou N" first="Nannan" last="Zhou">Nannan Zhou</name></noCountry><country name="Allemagne"><region name="Berlin"><name sortKey="Suss, Jochen" sort="Suss, Jochen" uniqKey="Suss J" first="Jochen" last="Süss">Jochen Süss</name></region></country><country name="Australie"><noRegion><name sortKey="Mackenzie, John" sort="Mackenzie, John" uniqKey="Mackenzie J" first="John" last="Mackenzie">John Mackenzie</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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